Motif ID: TFAP2{A,C}.p2

Z-value: 3.538


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)



Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_39573363 6.734 NM_002220
 ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr3_-_130807865 5.888 NM_015103
 PLXND1
plexin D1
chr15_-_81113676 4.804 NM_030594
 CPEB1
cytoplasmic polyadenylation element binding protein 1
chr15_+_64782468 4.789 SMAD6
SMAD family member 6
chr19_-_11452439 4.700 NM_001420
NM_032281
 ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr4_+_2031036 4.519 NM_178557
 NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr12_+_109956210 4.409 NM_015267
 CUX2
cut-like homeobox 2
chr9_+_125813849 4.320 LHX2
LIM homeobox 2
chr3_-_129689394 4.205 NM_001145662
 GATA2
GATA binding protein 2
chr9_+_94987032 4.117 NM_006648
 WNK2
WNK lysine deficient protein kinase 2
chr19_+_540849 4.045 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr1_+_1557419 3.963 NM_006983
 MMP23B
matrix metallopeptidase 23B
chr5_+_170668892 3.734 NM_021025
 TLX3
T-cell leukemia homeobox 3
chr16_-_87535106 3.726 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr12_+_2032649 3.703 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
 CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr8_-_144583718 3.597 NM_201589
 MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr2_+_120820140 3.559 NM_002193
 INHBB
inhibin, beta B
chr1_-_11674264 3.521 NM_001127325
 MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chrX_+_68641802 3.336 NM_015686
 FAM155B
family with sequence similarity 155, member B
chr8_+_104582151 3.293 NM_001100117
 RIMS2
regulating synaptic membrane exocytosis 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 195 entries
Enrichment   P-value GO Accession GO Term
22.11 1.82e-03 GO:0032332 positive regulation of chondrocyte differentiation
22.11 2.31e-02 GO:0030917 midbrain-hindbrain boundary development
19.66 4.08e-02 GO:0021903 rostrocaudal neural tube patterning
18.43 5.52e-03 GO:0003382 epithelial cell morphogenesis
15.80 1.34e-02 GO:0045686 negative regulation of glial cell differentiation
13.97 3.76e-03 GO:0035137 hindlimb morphogenesis
13.82 2.83e-02 GO:0021846 cell proliferation in forebrain
12.06 2.31e-07 GO:0048663 neuron fate commitment
12.06 9.75e-03 GO:0032330 regulation of chondrocyte differentiation
11.95 8.75e-06 GO:0001708 cell fate specification
11.06 1.69e-02 GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
10.32 5.15e-03 GO:0021515 cell differentiation in spinal cord
9.99 6.52e-03 GO:0061351 neural precursor cell proliferation
9.48 4.39e-02 GO:0072006 nephron development
9.41 1.06e-04 GO:0021510 spinal cord development
9.15 7.34e-06 GO:0050768 negative regulation of neurogenesis
8.62 2.18e-07 GO:0021953 central nervous system neuron differentiation
8.62 2.18e-07 GO:0042471 ear morphogenesis
8.60 1.88e-02 GO:0048332 mesoderm morphogenesis
8.37 2.27e-02 GO:0002064 epithelial cell development

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
5.09 4.45e-03 GO:0008076 voltage-gated potassium channel complex
5.09 4.45e-03 GO:0034705 potassium channel complex
4.26 2.02e-03 GO:0034703 cation channel complex
3.29 1.78e-03 GO:0005667 transcription factor complex
2.98 4.81e-02 GO:0034702 ion channel complex
2.93 5.24e-03 GO:0044456 synapse part
2.86 4.64e-04 GO:0045202 synapse
2.61 3.60e-02 GO:0005578 proteinaceous extracellular matrix
2.45 3.79e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
12.29 1.12e-02 GO:0005109 frizzled binding
5.62 7.44e-06 GO:0005267 potassium channel activity
4.97 3.83e-03 GO:0005249 voltage-gated potassium channel activity
4.67 2.32e-04 GO:0022843 voltage-gated cation channel activity
4.50 1.48e-05 GO:0005244 voltage-gated ion channel activity
4.50 1.48e-05 GO:0022832 voltage-gated channel activity
4.44 4.51e-22 GO:0043565 sequence-specific DNA binding
3.86 1.07e-05 GO:0005261 cation channel activity
3.74 1.75e-22 GO:0001071 nucleic acid binding transcription factor activity
3.74 1.75e-22 GO:0003700 sequence-specific DNA binding transcription factor activity
3.71 2.99e-06 GO:0016563 transcription activator activity
3.68 7.02e-06 GO:0022836 gated channel activity
3.62 2.80e-21 GO:0030528 transcription regulator activity
3.29 1.69e-02 GO:0000975 regulatory region DNA binding
3.29 1.69e-02 GO:0001067 regulatory region nucleic acid binding
3.29 1.69e-02 GO:0044212 transcription regulatory region DNA binding
3.19 4.02e-02 GO:0010843 promoter binding
3.02 1.80e-04 GO:0005216 ion channel activity
2.97 2.42e-04 GO:0022838 substrate-specific channel activity
2.88 4.29e-04 GO:0015267 channel activity